The research agenda for trauma critical care.
Identifieur interne : 000160 ( PubMed/Checkpoint ); précédent : 000159; suivant : 000161The research agenda for trauma critical care.
Auteurs : Karim Asehnoune [France] ; Zsolt Balogh [Australie] ; Giuseppe Citerio [Italie] ; Andre Cap [États-Unis] ; Timothy Billiar [États-Unis] ; Nino Stocchetti [Italie] ; Mitchell J. Cohen [États-Unis] ; Paolo Pelosi [Italie] ; Nicola Curry [Royaume-Uni] ; Christine Gaarder [Norvège] ; Russell Gruen [Singapour] ; John Holcomb [États-Unis] ; Beverley J. Hunt [Royaume-Uni] ; Nicole P. Juffermans [Pays-Bas] ; Mark Maegele [Allemagne] ; Mark Midwinter [Australie] ; Frederick A. Moore [États-Unis] ; Michael O'Dwyer [Royaume-Uni] ; Jean-François Pittet [États-Unis] ; Herbert Schöchl [Autriche] ; Martin Schreiber [États-Unis] ; Philip C. Spinella [États-Unis] ; Simon Stanworth [Royaume-Uni] ; Robert Winfield [États-Unis] ; Karim Brohi [Royaume-Uni]Source :
- Intensive care medicine [ 1432-1238 ] ; 2017.
Abstract
In this research agenda on the acute and critical care management of trauma patients, we concentrate on the major factors leading to death, namely haemorrhage and traumatic brain injury (TBI). In haemostasis biology, the results of randomised controlled trials have led to the therapeutic focus moving away from the augmentation of coagulation factors (such as recombinant factor VIIa) and towards fibrinogen supplementation and administration of antifibrinolytics such as tranexamic acid. Novel diagnostic techniques need to be evaluated to determine whether an individualised precision approach is superior to current empirical practice. The timing and efficacy of platelet transfusions remain in question, while new blood products need to be developed and evaluated, including whole blood variants, lyophilised products and novel red cell storage modalities. The current cornerstones of TBI management are intracranial pressure control, maintenance of cerebral perfusion pressure and avoidance of secondary insults (such as hypotension, hypoxaemia, hyperglycaemia and pyrexia). Therapeutic hypothermia and decompressive craniectomy are controversial therapies. Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Prediction of the long-term outcome early after TBI remains challenging. Early magnetic resonance imaging has recently been evaluated for predicting the long-term outcome in mild and severe TBI. Novel biomarkers may also help in outcome prediction and may predict chronic neurological symptoms. For trauma in general, rehabilitation is complex and multidimensional, and the optimal timing for commencement of rehabilitation needs investigation. We propose priority areas for clinical trials in the next 10 years.
DOI: 10.1007/s00134-017-4895-9
PubMed: 28756471
Affiliations:
- Allemagne, Australie, Autriche, France, Italie, Norvège, Pays-Bas, Royaume-Uni, Singapour, États-Unis
- Alabama, Angleterre, Floride, Grand Londres, Hollande-Septentrionale, Kansas, Lombardie, Oregon, Oxfordshire, Pays de la Loire, Pennsylvanie, Texas, Washington (État), Østlandet
- Amsterdam, Lawrence (Kansas), Londres, Milan, Nantes, Oslo, Oxford, Pittsburgh
- Université de Londres, Université de Pittsburgh, Université du Kansas
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Karim.Asehnoune@chu-nantes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology and Critical Care Medicine, Hôtel Dieu, Centre hospitalier universitaire (CHU) de Nantes, 44000, Nantes</wicri:regionArea><wicri:noRegion>44000, Nantes</wicri:noRegion><wicri:noRegion>44000, Nantes</wicri:noRegion></affiliation></author><author><name sortKey="Balogh, Zsolt" sort="Balogh, Zsolt" uniqKey="Balogh Z" first="Zsolt" last="Balogh">Zsolt Balogh</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital and University of Newcastle, Newcastle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital and University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Citerio, Giuseppe" sort="Citerio, Giuseppe" uniqKey="Citerio G" first="Giuseppe" last="Citerio">Giuseppe Citerio</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>School of Medicine and Surgery, University of Milan-Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Cap, Andre" sort="Cap, Andre" uniqKey="Cap A" first="Andre" last="Cap">Andre Cap</name><affiliation wicri:level="2"><nlm:affiliation>US Army Institute of Surgical Research, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>US Army Institute of Surgical Research, San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Billiar, Timothy" sort="Billiar, Timothy" uniqKey="Billiar T" first="Timothy" last="Billiar">Timothy Billiar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, University of Pittsburgh, Pittsburgh, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Stocchetti, Nino" sort="Stocchetti, Nino" uniqKey="Stocchetti N" first="Nino" last="Stocchetti">Nino Stocchetti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Physiopathology and Transplant, Milan University and Neuro ICU Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplant, Milan University and Neuro ICU Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Cohen, Mitchell J" sort="Cohen, Mitchell J" uniqKey="Cohen M" first="Mitchell J" last="Cohen">Mitchell J. Cohen</name><affiliation wicri:level="1"><nlm:affiliation>University of Colorado School of Medicine, Denver Health Medical Center, Aurora, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Colorado School of Medicine, Denver Health Medical Center, Aurora</wicri:regionArea><wicri:noRegion>Aurora</wicri:noRegion></affiliation></author><author><name sortKey="Pelosi, Paolo" sort="Pelosi, Paolo" uniqKey="Pelosi P" first="Paolo" last="Pelosi">Paolo Pelosi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino-IST, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Curry, Nicola" sort="Curry, Nicola" uniqKey="Curry N" first="Nicola" last="Curry">Nicola Curry</name><affiliation wicri:level="3"><nlm:affiliation>Oxford University Hospital NHS Trust, John Radcliffe Hospital, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford University Hospital NHS Trust, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gaarder, Christine" sort="Gaarder, Christine" uniqKey="Gaarder C" first="Christine" last="Gaarder">Christine Gaarder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Traumatology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Traumatology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Gruen, Russell" sort="Gruen, Russell" uniqKey="Gruen R" first="Russell" last="Gruen">Russell Gruen</name><affiliation wicri:level="1"><nlm:affiliation>Lee Kong Chian School of Medicine, Nanyang Technological University, Nanyang, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Nanyang Technological University, Nanyang</wicri:regionArea><wicri:noRegion>Nanyang</wicri:noRegion></affiliation></author><author><name sortKey="Holcomb, John" sort="Holcomb, John" uniqKey="Holcomb J" first="John" last="Holcomb">John Holcomb</name><affiliation wicri:level="2"><nlm:affiliation>Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hunt, Beverley J" sort="Hunt, Beverley J" uniqKey="Hunt B" first="Beverley J" last="Hunt">Beverley J. Hunt</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Haematology and Pathology, Guy's and St Thomas' NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Haematology and Pathology, Guy's and St Thomas' NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Juffermans, Nicole P" sort="Juffermans, Nicole P" uniqKey="Juffermans N" first="Nicole P" last="Juffermans">Nicole P. Juffermans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Intensive Care, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Maegele, Mark" sort="Maegele, Mark" uniqKey="Maegele M" first="Mark" last="Maegele">Mark Maegele</name><affiliation wicri:level="1"><nlm:affiliation>Department for Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Centre, University of Witten/Herdecke, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Centre, University of Witten/Herdecke, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Midwinter, Mark" sort="Midwinter, Mark" uniqKey="Midwinter M" first="Mark" last="Midwinter">Mark Midwinter</name><affiliation wicri:level="1"><nlm:affiliation>Rural Clinical School (Bundaberg), University of Queensland, Bundaberg, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rural Clinical School (Bundaberg), University of Queensland, Bundaberg, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Frederick A" sort="Moore, Frederick A" uniqKey="Moore F" first="Frederick A" last="Moore">Frederick A. Moore</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Florida, Gainesville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Florida, Gainesville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="O Dwyer, Michael" sort="O Dwyer, Michael" uniqKey="O Dwyer M" first="Michael" last="O'Dwyer">Michael O'Dwyer</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Trauma Sciences, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Trauma Sciences, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Pittet, Jean Francois" sort="Pittet, Jean Francois" uniqKey="Pittet J" first="Jean-François" last="Pittet">Jean-François Pittet</name><affiliation wicri:level="2"><nlm:affiliation>Critical Care Division, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Critical Care Division, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Schochl, Herbert" sort="Schochl, Herbert" uniqKey="Schochl H" first="Herbert" last="Schöchl">Herbert Schöchl</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Schreiber, Martin" sort="Schreiber, Martin" uniqKey="Schreiber M" first="Martin" last="Schreiber">Martin Schreiber</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Oregon Health and Science University, Portland, OR, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Oregon Health and Science University, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Spinella, Philip C" sort="Spinella, Philip C" uniqKey="Spinella P" first="Philip C" last="Spinella">Philip C. Spinella</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Washington University in St Louis School of Medicine, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Washington University in St Louis School of Medicine, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Stanworth, Simon" sort="Stanworth, Simon" uniqKey="Stanworth S" first="Simon" last="Stanworth">Simon Stanworth</name><affiliation wicri:level="3"><nlm:affiliation>NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Winfield, Robert" sort="Winfield, Robert" uniqKey="Winfield R" first="Robert" last="Winfield">Robert Winfield</name><affiliation wicri:level="4"><nlm:affiliation>University of Kansas, Medical Center, Kansas City, KS, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Kansas, Medical Center, Kansas City, KS</wicri:regionArea><placeName><region type="state">Kansas</region><settlement type="city">Lawrence (Kansas)</settlement></placeName><orgName type="university">Université du Kansas</orgName></affiliation></author><author><name sortKey="Brohi, Karim" sort="Brohi, Karim" uniqKey="Brohi K" first="Karim" last="Brohi">Karim Brohi</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Trauma Sciences, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Trauma Sciences, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28756471</idno><idno type="pmid">28756471</idno><idno type="doi">10.1007/s00134-017-4895-9</idno><idno type="wicri:Area/PubMed/Corpus">000859</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000859</idno><idno type="wicri:Area/PubMed/Curation">000856</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000856</idno><idno type="wicri:Area/PubMed/Checkpoint">000856</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000856</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The research agenda for trauma critical care.</title><author><name sortKey="Asehnoune, Karim" sort="Asehnoune, Karim" uniqKey="Asehnoune K" first="Karim" last="Asehnoune">Karim Asehnoune</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anesthesiology and Critical Care Medicine, Hôtel Dieu, Centre hospitalier universitaire (CHU) de Nantes, 44000, Nantes, France. Karim.Asehnoune@chu-nantes.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Anesthesiology and Critical Care Medicine, Hôtel Dieu, Centre hospitalier universitaire (CHU) de Nantes, 44000, Nantes</wicri:regionArea><placeName><region type="region" nuts="2">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Balogh, Zsolt" sort="Balogh, Zsolt" uniqKey="Balogh Z" first="Zsolt" last="Balogh">Zsolt Balogh</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital and University of Newcastle, Newcastle, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital and University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Citerio, Giuseppe" sort="Citerio, Giuseppe" uniqKey="Citerio G" first="Giuseppe" last="Citerio">Giuseppe Citerio</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>School of Medicine and Surgery, University of Milan-Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Cap, Andre" sort="Cap, Andre" uniqKey="Cap A" first="Andre" last="Cap">Andre Cap</name><affiliation wicri:level="2"><nlm:affiliation>US Army Institute of Surgical Research, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>US Army Institute of Surgical Research, San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Billiar, Timothy" sort="Billiar, Timothy" uniqKey="Billiar T" first="Timothy" last="Billiar">Timothy Billiar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Surgery, University of Pittsburgh, Pittsburgh, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Pittsburgh, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Stocchetti, Nino" sort="Stocchetti, Nino" uniqKey="Stocchetti N" first="Nino" last="Stocchetti">Nino Stocchetti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Physiopathology and Transplant, Milan University and Neuro ICU Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplant, Milan University and Neuro ICU Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Cohen, Mitchell J" sort="Cohen, Mitchell J" uniqKey="Cohen M" first="Mitchell J" last="Cohen">Mitchell J. Cohen</name><affiliation wicri:level="1"><nlm:affiliation>University of Colorado School of Medicine, Denver Health Medical Center, Aurora, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Colorado School of Medicine, Denver Health Medical Center, Aurora</wicri:regionArea><wicri:noRegion>Aurora</wicri:noRegion></affiliation></author><author><name sortKey="Pelosi, Paolo" sort="Pelosi, Paolo" uniqKey="Pelosi P" first="Paolo" last="Pelosi">Paolo Pelosi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino-IST, University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Curry, Nicola" sort="Curry, Nicola" uniqKey="Curry N" first="Nicola" last="Curry">Nicola Curry</name><affiliation wicri:level="3"><nlm:affiliation>Oxford University Hospital NHS Trust, John Radcliffe Hospital, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford University Hospital NHS Trust, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Gaarder, Christine" sort="Gaarder, Christine" uniqKey="Gaarder C" first="Christine" last="Gaarder">Christine Gaarder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Traumatology, Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Traumatology, Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Gruen, Russell" sort="Gruen, Russell" uniqKey="Gruen R" first="Russell" last="Gruen">Russell Gruen</name><affiliation wicri:level="1"><nlm:affiliation>Lee Kong Chian School of Medicine, Nanyang Technological University, Nanyang, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Lee Kong Chian School of Medicine, Nanyang Technological University, Nanyang</wicri:regionArea><wicri:noRegion>Nanyang</wicri:noRegion></affiliation></author><author><name sortKey="Holcomb, John" sort="Holcomb, John" uniqKey="Holcomb J" first="John" last="Holcomb">John Holcomb</name><affiliation wicri:level="2"><nlm:affiliation>Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Hunt, Beverley J" sort="Hunt, Beverley J" uniqKey="Hunt B" first="Beverley J" last="Hunt">Beverley J. Hunt</name><affiliation wicri:level="3"><nlm:affiliation>Departments of Haematology and Pathology, Guy's and St Thomas' NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Departments of Haematology and Pathology, Guy's and St Thomas' NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Juffermans, Nicole P" sort="Juffermans, Nicole P" uniqKey="Juffermans N" first="Nicole P" last="Juffermans">Nicole P. Juffermans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Intensive Care, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Maegele, Mark" sort="Maegele, Mark" uniqKey="Maegele M" first="Mark" last="Maegele">Mark Maegele</name><affiliation wicri:level="1"><nlm:affiliation>Department for Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Centre, University of Witten/Herdecke, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Centre, University of Witten/Herdecke, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Midwinter, Mark" sort="Midwinter, Mark" uniqKey="Midwinter M" first="Mark" last="Midwinter">Mark Midwinter</name><affiliation wicri:level="1"><nlm:affiliation>Rural Clinical School (Bundaberg), University of Queensland, Bundaberg, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Rural Clinical School (Bundaberg), University of Queensland, Bundaberg, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Moore, Frederick A" sort="Moore, Frederick A" uniqKey="Moore F" first="Frederick A" last="Moore">Frederick A. Moore</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Florida, Gainesville, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Florida, Gainesville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="O Dwyer, Michael" sort="O Dwyer, Michael" uniqKey="O Dwyer M" first="Michael" last="O'Dwyer">Michael O'Dwyer</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Trauma Sciences, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Trauma Sciences, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Pittet, Jean Francois" sort="Pittet, Jean Francois" uniqKey="Pittet J" first="Jean-François" last="Pittet">Jean-François Pittet</name><affiliation wicri:level="2"><nlm:affiliation>Critical Care Division, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Critical Care Division, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Schochl, Herbert" sort="Schochl, Herbert" uniqKey="Schochl H" first="Herbert" last="Schöchl">Herbert Schöchl</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation></author><author><name sortKey="Schreiber, Martin" sort="Schreiber, Martin" uniqKey="Schreiber M" first="Martin" last="Schreiber">Martin Schreiber</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Oregon Health and Science University, Portland, OR, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Oregon Health and Science University, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Spinella, Philip C" sort="Spinella, Philip C" uniqKey="Spinella P" first="Philip C" last="Spinella">Philip C. Spinella</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Washington University in St Louis School of Medicine, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Washington University in St Louis School of Medicine, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Stanworth, Simon" sort="Stanworth, Simon" uniqKey="Stanworth S" first="Simon" last="Stanworth">Simon Stanworth</name><affiliation wicri:level="3"><nlm:affiliation>NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS Blood and Transplant, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Winfield, Robert" sort="Winfield, Robert" uniqKey="Winfield R" first="Robert" last="Winfield">Robert Winfield</name><affiliation wicri:level="4"><nlm:affiliation>University of Kansas, Medical Center, Kansas City, KS, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Kansas, Medical Center, Kansas City, KS</wicri:regionArea><placeName><region type="state">Kansas</region><settlement type="city">Lawrence (Kansas)</settlement></placeName><orgName type="university">Université du Kansas</orgName></affiliation></author><author><name sortKey="Brohi, Karim" sort="Brohi, Karim" uniqKey="Brohi K" first="Karim" last="Brohi">Karim Brohi</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Trauma Sciences, Queen Mary University of London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Trauma Sciences, Queen Mary University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></analytic><series><title level="j">Intensive care medicine</title><idno type="eISSN">1432-1238</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this research agenda on the acute and critical care management of trauma patients, we concentrate on the major factors leading to death, namely haemorrhage and traumatic brain injury (TBI). In haemostasis biology, the results of randomised controlled trials have led to the therapeutic focus moving away from the augmentation of coagulation factors (such as recombinant factor VIIa) and towards fibrinogen supplementation and administration of antifibrinolytics such as tranexamic acid. Novel diagnostic techniques need to be evaluated to determine whether an individualised precision approach is superior to current empirical practice. The timing and efficacy of platelet transfusions remain in question, while new blood products need to be developed and evaluated, including whole blood variants, lyophilised products and novel red cell storage modalities. The current cornerstones of TBI management are intracranial pressure control, maintenance of cerebral perfusion pressure and avoidance of secondary insults (such as hypotension, hypoxaemia, hyperglycaemia and pyrexia). Therapeutic hypothermia and decompressive craniectomy are controversial therapies. Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Prediction of the long-term outcome early after TBI remains challenging. Early magnetic resonance imaging has recently been evaluated for predicting the long-term outcome in mild and severe TBI. Novel biomarkers may also help in outcome prediction and may predict chronic neurological symptoms. For trauma in general, rehabilitation is complex and multidimensional, and the optimal timing for commencement of rehabilitation needs investigation. We propose priority areas for clinical trials in the next 10 years.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28756471</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>30</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Jul</Month><Day>29</Day></PubDate></JournalIssue><Title>Intensive care medicine</Title><ISOAbbreviation>Intensive Care Med</ISOAbbreviation></Journal><ArticleTitle>The research agenda for trauma critical care.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-017-4895-9</ELocationID><Abstract><AbstractText>In this research agenda on the acute and critical care management of trauma patients, we concentrate on the major factors leading to death, namely haemorrhage and traumatic brain injury (TBI). In haemostasis biology, the results of randomised controlled trials have led to the therapeutic focus moving away from the augmentation of coagulation factors (such as recombinant factor VIIa) and towards fibrinogen supplementation and administration of antifibrinolytics such as tranexamic acid. Novel diagnostic techniques need to be evaluated to determine whether an individualised precision approach is superior to current empirical practice. The timing and efficacy of platelet transfusions remain in question, while new blood products need to be developed and evaluated, including whole blood variants, lyophilised products and novel red cell storage modalities. The current cornerstones of TBI management are intracranial pressure control, maintenance of cerebral perfusion pressure and avoidance of secondary insults (such as hypotension, hypoxaemia, hyperglycaemia and pyrexia). Therapeutic hypothermia and decompressive craniectomy are controversial therapies. Further research into these strategies should focus on identifying which subgroups of patients may benefit from these interventions. Prediction of the long-term outcome early after TBI remains challenging. Early magnetic resonance imaging has recently been evaluated for predicting the long-term outcome in mild and severe TBI. Novel biomarkers may also help in outcome prediction and may predict chronic neurological symptoms. For trauma in general, rehabilitation is complex and multidimensional, and the optimal timing for commencement of rehabilitation needs investigation. We propose priority areas for clinical trials in the next 10 years.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Asehnoune</LastName><ForeName>Karim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Critical Care Medicine, Hôtel Dieu, Centre hospitalier universitaire (CHU) de Nantes, 44000, Nantes, France. Karim.Asehnoune@chu-nantes.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory EA 3826, University of Nantes, Nantes, France. Karim.Asehnoune@chu-nantes.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balogh</LastName><ForeName>Zsolt</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>John Hunter Hospital and University of Newcastle, Newcastle, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Citerio</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neurointensive Care Unit, Department of Emergency and Intensive Care, San Gerardo Hospital, ASST-Monza, Monza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cap</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>US Army Institute of Surgical Research, San Antonio, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Billiar</LastName><ForeName>Timothy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pittsburgh, Pittsburgh, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stocchetti</LastName><ForeName>Nino</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Physiopathology and Transplant, Milan University and Neuro ICU Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Mitchell J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>University of Colorado School of Medicine, Denver Health Medical Center, Aurora, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pelosi</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Surgical Sciences and Integrated Diagnostics, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curry</LastName><ForeName>Nicola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Oxford University Hospital NHS Trust, John Radcliffe Hospital, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaarder</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Traumatology, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruen</LastName><ForeName>Russell</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Lee Kong Chian School of Medicine, Nanyang Technological University, Nanyang, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holcomb</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunt</LastName><ForeName>Beverley J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Departments of Haematology and Pathology, Guy's and St Thomas' NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Juffermans</LastName><ForeName>Nicole P</ForeName><Initials>NP</Initials><AffiliationInfo><Affiliation>Department of Intensive Care, Academic Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maegele</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department for Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Centre, University of Witten/Herdecke, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Midwinter</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Rural Clinical School (Bundaberg), University of Queensland, Bundaberg, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moore</LastName><ForeName>Frederick A</ForeName><Initials>FA</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Florida, Gainesville, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Dwyer</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Trauma Sciences, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pittet</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Critical Care Division, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schöchl</LastName><ForeName>Herbert</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Intensive Care Medicine, AUVA Trauma Centre Salzburg, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schreiber</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Surgery, Oregon Health and Science University, Portland, OR, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spinella</LastName><ForeName>Philip C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Washington University in St Louis School of Medicine, Washington, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stanworth</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winfield</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of Kansas, Medical Center, Kansas City, KS, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brohi</LastName><ForeName>Karim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Centre for Trauma Sciences, Queen Mary University of London, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate 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injury</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>07</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28756471</ArticleId><ArticleId IdType="doi">10.1007/s00134-017-4895-9</ArticleId><ArticleId IdType="pii">10.1007/s00134-017-4895-9</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>France</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Singapour</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Floride</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Kansas</li><li>Lombardie</li><li>Oregon</li><li>Oxfordshire</li><li>Pays de la Loire</li><li>Pennsylvanie</li><li>Texas</li><li>Washington (État)</li><li>Østlandet</li></region><settlement><li>Amsterdam</li><li>Lawrence (Kansas)</li><li>Londres</li><li>Milan</li><li>Nantes</li><li>Oslo</li><li>Oxford</li><li>Pittsburgh</li></settlement><orgName><li>Université de Londres</li><li>Université de Pittsburgh</li><li>Université du Kansas</li></orgName></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Asehnoune, Karim" sort="Asehnoune, Karim" uniqKey="Asehnoune K" first="Karim" last="Asehnoune">Karim Asehnoune</name></region></country><country name="Australie"><noRegion><name sortKey="Balogh, Zsolt" sort="Balogh, Zsolt" uniqKey="Balogh Z" first="Zsolt" last="Balogh">Zsolt Balogh</name></noRegion><name sortKey="Midwinter, Mark" sort="Midwinter, Mark" uniqKey="Midwinter M" first="Mark" last="Midwinter">Mark Midwinter</name></country><country name="Italie"><noRegion><name sortKey="Citerio, Giuseppe" sort="Citerio, Giuseppe" uniqKey="Citerio G" first="Giuseppe" last="Citerio">Giuseppe Citerio</name></noRegion><name sortKey="Pelosi, Paolo" sort="Pelosi, Paolo" uniqKey="Pelosi P" first="Paolo" last="Pelosi">Paolo Pelosi</name><name sortKey="Stocchetti, Nino" sort="Stocchetti, Nino" uniqKey="Stocchetti N" first="Nino" last="Stocchetti">Nino Stocchetti</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Cap, Andre" sort="Cap, Andre" uniqKey="Cap A" first="Andre" last="Cap">Andre Cap</name></region><name sortKey="Billiar, Timothy" sort="Billiar, Timothy" uniqKey="Billiar T" first="Timothy" last="Billiar">Timothy Billiar</name><name sortKey="Cohen, Mitchell J" sort="Cohen, Mitchell J" uniqKey="Cohen M" first="Mitchell J" last="Cohen">Mitchell J. Cohen</name><name sortKey="Holcomb, John" sort="Holcomb, John" uniqKey="Holcomb J" first="John" last="Holcomb">John Holcomb</name><name sortKey="Moore, Frederick A" sort="Moore, Frederick A" uniqKey="Moore F" first="Frederick A" last="Moore">Frederick A. Moore</name><name sortKey="Pittet, Jean Francois" sort="Pittet, Jean Francois" uniqKey="Pittet J" first="Jean-François" last="Pittet">Jean-François Pittet</name><name sortKey="Schreiber, Martin" sort="Schreiber, Martin" uniqKey="Schreiber M" first="Martin" last="Schreiber">Martin Schreiber</name><name sortKey="Spinella, Philip C" sort="Spinella, Philip C" uniqKey="Spinella P" first="Philip C" last="Spinella">Philip C. Spinella</name><name sortKey="Winfield, Robert" sort="Winfield, Robert" uniqKey="Winfield R" first="Robert" last="Winfield">Robert Winfield</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Curry, Nicola" sort="Curry, Nicola" uniqKey="Curry N" first="Nicola" last="Curry">Nicola Curry</name></region><name sortKey="Brohi, Karim" sort="Brohi, Karim" uniqKey="Brohi K" first="Karim" last="Brohi">Karim Brohi</name><name sortKey="Hunt, Beverley J" sort="Hunt, Beverley J" uniqKey="Hunt B" first="Beverley J" last="Hunt">Beverley J. Hunt</name><name sortKey="O Dwyer, Michael" sort="O Dwyer, Michael" uniqKey="O Dwyer M" first="Michael" last="O'Dwyer">Michael O'Dwyer</name><name sortKey="Stanworth, Simon" sort="Stanworth, Simon" uniqKey="Stanworth S" first="Simon" last="Stanworth">Simon Stanworth</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Gaarder, Christine" sort="Gaarder, Christine" uniqKey="Gaarder C" first="Christine" last="Gaarder">Christine Gaarder</name></region></country><country name="Singapour"><noRegion><name sortKey="Gruen, Russell" sort="Gruen, Russell" uniqKey="Gruen R" first="Russell" last="Gruen">Russell Gruen</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Juffermans, Nicole P" sort="Juffermans, Nicole P" uniqKey="Juffermans N" first="Nicole P" last="Juffermans">Nicole P. Juffermans</name></region></country><country name="Allemagne"><noRegion><name sortKey="Maegele, Mark" sort="Maegele, Mark" uniqKey="Maegele M" first="Mark" last="Maegele">Mark Maegele</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Schochl, Herbert" sort="Schochl, Herbert" uniqKey="Schochl H" first="Herbert" last="Schöchl">Herbert Schöchl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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